Tissue expression of TRMT10A - Summary - The Human Protein Atlas

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TRMT10A

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TRMT10A
Gene description	TRNA methyltransferase 10A
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047601
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TRMT10A (HGNC Symbol)
Synonyms	MGC27034, RG9MTD2, TRM10
Description	TRNA methyltransferase 10A (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Chromosome	4
Cytoband	q23
Chromosome location (bp)	99546709 - 99564032
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145331 (version 83.38)
Entrez gene	93587
UniProt	Q8TBZ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBZ6
Antibodypedia	TRMT10A antibodies

PROTEIN BROWSER

TRMT10A-001	TRMT10A-002	TRMT10A-003	TRMT10A-004	TRMT10A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRMT10A-001 ENSP00000378343 ENST00000394877	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-002 ENSP00000378342 ENST00000394876	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-003 ENSP00000273962 ENST00000273962	Q8TBZ6 [Direct mapping] tRNA methyltransferase 10 homolog A V9HVY8 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 88; RNA (Guanine-9-) methyltransferase domain containing 2, isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006400 [tRNA modification] GO:0008033 [tRNA processing] GO:0008168 [methyltransferase activity] GO:0010467 [gene expression] GO:0030488 [tRNA methylation] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	339 aa 39.7 kDa	No	0
TRMT10A-004 ENSP00000423628 ENST00000514547	D6R954 [Direct mapping] tRNA methyltransferase 10 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		200 aa 24 kDa	No	0
TRMT10A-005 ENSP00000397551 ENST00000455368	X6REK4 [Direct mapping] tRNA methyltransferase 10 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		206 aa 24.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.