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Several cases of liver and endometrial cancers showed moderate to strong cytoplasmic staining while lung cancers displayed moderate positivity. Several renal and pancreatic cancers exhibited weak to moderate cytoplasmic and membranous staining. Remaining cancer tissues were weakly stained or negative.
Moderate to strong cytoplasmic positivity was observed in a few gliomas. A few cases of thyroid, urothelial, testicular, colorectal, prostate and endometrial cancers showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
CAMK2D (HGNC Symbol)
Synonyms
CAMKD
Description
Calcium/calmodulin-dependent protein kinase II delta (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta A0A024RDK3 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_a
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0002026 [regulation of the force of heart contraction] GO:0002028 [regulation of sodium ion transport] GO:0003254 [regulation of membrane depolarization] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006816 [calcium ion transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008016 [regulation of heart contraction] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014704 [intercalated disc] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016529 [sarcoplasmic reticulum] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0030007 [cellular potassium ion homeostasis] GO:0030315 [T-tubule] GO:0030666 [endocytic vesicle membrane] GO:0031432 [titin binding] GO:0031594 [neuromuscular junction] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0034704 [calcium channel complex] GO:0035022 [positive regulation of Rac protein signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043194 [axon initial segment] GO:0043234 [protein complex] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050998 [nitric-oxide synthase binding] GO:0051259 [protein oligomerization] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060341 [regulation of cellular localization] GO:0061049 [cell growth involved in cardiac muscle cell development] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071277 [cellular response to calcium ion] GO:0086003 [cardiac muscle cell contraction] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0098901 [regulation of cardiac muscle cell action potential] GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:1900034 [regulation of cellular response to heat] GO:1901725 [regulation of histone deacetylase activity] GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897 [regulation of relaxation of cardiac muscle] GO:1902306 [negative regulation of sodium ion transmembrane transport] GO:1902514 [regulation of generation of L-type calcium current] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
D6R938 [Direct mapping] Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_e; Calcium/calmodulin-dependent protein kinase type II subunit delta
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)