We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Calcium/calmodulin-dependent protein kinase II delta (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]
Q13557 [Direct mapping] Calcium/calmodulin-dependent protein kinase type II subunit delta A0A024RDK3 [Target identity:100%; Query identity:100%] Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_a
Show all
Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0002026 [regulation of the force of heart contraction] GO:0002028 [regulation of sodium ion transport] GO:0003254 [regulation of membrane depolarization] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0006816 [calcium ion transport] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0008016 [regulation of heart contraction] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0010389 [regulation of G2/M transition of mitotic cell cycle] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0010649 [regulation of cell communication by electrical coupling] GO:0010666 [positive regulation of cardiac muscle cell apoptotic process] GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014704 [intercalated disc] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016529 [sarcoplasmic reticulum] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019221 [cytokine-mediated signaling pathway] GO:0019871 [sodium channel inhibitor activity] GO:0030007 [cellular potassium ion homeostasis] GO:0030315 [T-tubule] GO:0030666 [endocytic vesicle membrane] GO:0031432 [titin binding] GO:0031594 [neuromuscular junction] GO:0032469 [endoplasmic reticulum calcium ion homeostasis] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034605 [cellular response to heat] GO:0034704 [calcium channel complex] GO:0035022 [positive regulation of Rac protein signal transduction] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042383 [sarcolemma] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0043194 [axon initial segment] GO:0043234 [protein complex] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0046777 [protein autophosphorylation] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050998 [nitric-oxide synthase binding] GO:0051259 [protein oligomerization] GO:0055119 [relaxation of cardiac muscle] GO:0060048 [cardiac muscle contraction] GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060341 [regulation of cellular localization] GO:0061049 [cell growth involved in cardiac muscle cell development] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0071277 [cellular response to calcium ion] GO:0086003 [cardiac muscle cell contraction] GO:0086091 [regulation of heart rate by cardiac conduction] GO:0098901 [regulation of cardiac muscle cell action potential] GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction] GO:1900034 [regulation of cellular response to heat] GO:1901725 [regulation of histone deacetylase activity] GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction] GO:1901897 [regulation of relaxation of cardiac muscle] GO:1902306 [negative regulation of sodium ion transmembrane transport] GO:1902514 [regulation of generation of L-type calcium current] GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
D6R938 [Direct mapping] Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_e; Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014)