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ANK2

GENERAL INFORMATION

Gene name

 ANK2

Gene description

 Ankyrin 2, neuronal

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues. High abundance in the brain, peripheral nerves, renal collecting ducts and the adrenal gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008007 , HPA035970 , CAB015178
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Soft tissue

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 ANK2 (HGNC Symbol)

Synonyms

 LQT4

Description

 Ankyrin 2, neuronal (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Dec 2011]

Chromosome

 4

Cytoband

Chromosome location (bp)

 112818109 - 113383740

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145362 (version 83.38)

Entrez gene

 287

UniProt

 Q01484 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01484

Antibodypedia

 ANK2 antibodies

PROTEIN BROWSER
«
ANK2-001
ANK2-002
ANK2-004
ANK2-005
ANK2-006
ANK2-007
ANK2-008
ANK2-009
ANK2-010
ANK2-011
ANK2-013
ANK2-014
ANK2-015
ANK2-022
ANK2-023
ANK2-024
ANK2-026
ANK2-027
ANK2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANK2-001
ENSP00000349588
ENST00000357077
Q01484 [Direct mapping]
Ankyrin-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0003283 [atrial septum development]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0008104 [protein localization]
GO:0010628 [positive regulation of gene expression]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0015459 [potassium channel regulator activity]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0030913 [paranodal junction assembly]
GO:0031430 [M band]
GO:0031647 [regulation of protein stability]
GO:0031672 [A band]
GO:0033292 [T-tubule organization]
GO:0033365 [protein localization to organelle]
GO:0034394 [protein localization to cell surface]
GO:0034613 [cellular protein localization]
GO:0036309 [protein localization to M-band]
GO:0036371 [protein localization to T-tubule]
GO:0042383 [sarcolemma]
GO:0043005 [neuron projection]
GO:0043034 [costamere]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0045211 [postsynaptic membrane]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051117 [ATPase binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051597 [response to methylmercury]
GO:0051924 [regulation of calcium ion transport]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060048 [cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0072659 [protein localization to plasma membrane]
GO:0072661 [protein targeting to plasma membrane]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086046 [membrane depolarization during SA node cell action potential]
GO:0086066 [atrial cardiac muscle cell to AV node cell communication]
GO:0086070 [SA node cell to atrial cardiac muscle cell communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097481 [neuronal postsynaptic density]
GO:0098904 [regulation of AV node cell action potential]
GO:0098907 [regulation of SA node cell action potential]
GO:0098910 [regulation of atrial cardiac muscle cell action potential]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901019 [regulation of calcium ion transmembrane transporter activity]
GO:1901021 [positive regulation of calcium ion transmembrane transporter activity]
GO:2001257 [regulation of cation channel activity]
GO:2001259 [positive regulation of cation channel activity]
Show all
 3957 aa
433.7 kDa 		No 0
ANK2-002
ENSP00000378044
ENST00000394537
Q01484 [Direct mapping]
Ankyrin-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0003283 [atrial septum development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0010628 [positive regulation of gene expression]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0031430 [M band]
GO:0031647 [regulation of protein stability]
GO:0031672 [A band]
GO:0033292 [T-tubule organization]
GO:0033365 [protein localization to organelle]
GO:0034394 [protein localization to cell surface]
GO:0034613 [cellular protein localization]
GO:0036309 [protein localization to M-band]
GO:0036371 [protein localization to T-tubule]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0050821 [protein stabilization]
GO:0051117 [ATPase binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051924 [regulation of calcium ion transport]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0072659 [protein localization to plasma membrane]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086046 [membrane depolarization during SA node cell action potential]
GO:0086066 [atrial cardiac muscle cell to AV node cell communication]
GO:0086070 [SA node cell to atrial cardiac muscle cell communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098907 [regulation of SA node cell action potential]
GO:0098910 [regulation of atrial cardiac muscle cell action potential]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901019 [regulation of calcium ion transmembrane transporter activity]
GO:1901021 [positive regulation of calcium ion transmembrane transporter activity]
GO:2001259 [positive regulation of cation channel activity]
Show all
 1872 aa
205.8 kDa 		No 0
ANK2-004
ENSP00000421067
ENST00000506722
Q01484 [Direct mapping]
Ankyrin-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0003283 [atrial septum development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0010628 [positive regulation of gene expression]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0031430 [M band]
GO:0031647 [regulation of protein stability]
GO:0031672 [A band]
GO:0033292 [T-tubule organization]
GO:0033365 [protein localization to organelle]
GO:0034394 [protein localization to cell surface]
GO:0034613 [cellular protein localization]
GO:0036309 [protein localization to M-band]
GO:0036371 [protein localization to T-tubule]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0050821 [protein stabilization]
GO:0051117 [ATPase binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051924 [regulation of calcium ion transport]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0072659 [protein localization to plasma membrane]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086046 [membrane depolarization during SA node cell action potential]
GO:0086066 [atrial cardiac muscle cell to AV node cell communication]
GO:0086070 [SA node cell to atrial cardiac muscle cell communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098907 [regulation of SA node cell action potential]
GO:0098910 [regulation of atrial cardiac muscle cell action potential]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901019 [regulation of calcium ion transmembrane transporter activity]
GO:1901021 [positive regulation of calcium ion transmembrane transporter activity]
GO:2001259 [positive regulation of cation channel activity]
Show all
 1863 aa
204.8 kDa 		No 0
ANK2-005
ENSP00000424722
ENST00000504454
E9PHW9 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1730 aa
189.1 kDa 		No 0
ANK2-006
ENSP00000426944
ENST00000509550
E9PCH6 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 1048 aa
117.8 kDa 		No 0
ANK2-007
ENSP00000422853
ENST00000514960
H0Y931 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 966 aa
108.6 kDa 		No 0
ANK2-008
ENSP00000421023
ENST00000510275
Q01484 [Direct mapping]
Ankyrin-2
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0003283 [atrial septum development]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007165 [signal transduction]
GO:0007411 [axon guidance]
GO:0010628 [positive regulation of gene expression]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0010882 [regulation of cardiac muscle contraction by calcium ion signaling]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0030018 [Z disc]
GO:0030315 [T-tubule]
GO:0030507 [spectrin binding]
GO:0030674 [protein binding, bridging]
GO:0031430 [M band]
GO:0031647 [regulation of protein stability]
GO:0031672 [A band]
GO:0033292 [T-tubule organization]
GO:0033365 [protein localization to organelle]
GO:0034394 [protein localization to cell surface]
GO:0034613 [cellular protein localization]
GO:0036309 [protein localization to M-band]
GO:0036371 [protein localization to T-tubule]
GO:0042383 [sarcolemma]
GO:0043034 [costamere]
GO:0043268 [positive regulation of potassium ion transport]
GO:0044325 [ion channel binding]
GO:0045211 [postsynaptic membrane]
GO:0050821 [protein stabilization]
GO:0051117 [ATPase binding]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0051924 [regulation of calcium ion transport]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060307 [regulation of ventricular cardiac muscle cell membrane repolarization]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070972 [protein localization to endoplasmic reticulum]
GO:0072659 [protein localization to plasma membrane]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086005 [ventricular cardiac muscle cell action potential]
GO:0086014 [atrial cardiac muscle cell action potential]
GO:0086015 [SA node cell action potential]
GO:0086046 [membrane depolarization during SA node cell action potential]
GO:0086066 [atrial cardiac muscle cell to AV node cell communication]
GO:0086070 [SA node cell to atrial cardiac muscle cell communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098907 [regulation of SA node cell action potential]
GO:0098910 [regulation of atrial cardiac muscle cell action potential]
GO:1901018 [positive regulation of potassium ion transmembrane transporter activity]
GO:1901019 [regulation of calcium ion transmembrane transporter activity]
GO:1901021 [positive regulation of calcium ion transmembrane transporter activity]
GO:2001259 [positive regulation of cation channel activity]
Show all
 555 aa
63.4 kDa 		No 0
ANK2-009
ENSP00000423799
ENST00000503271
B7Z651 [Direct mapping]
Ankyrin-2; cDNA FLJ61595, highly similar to Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1114 aa
119.9 kDa 		No 0
ANK2-010
ENSP00000421011
ENST00000503423
D6RHE1 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1611 aa
176.1 kDa 		No 0
ANK2-011
ENSP00000422498
ENST00000505342
H0Y8Y2 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 1028 aa
114.7 kDa 		No 0
ANK2-013
ENSP00000422900
ENST00000508613
D6R9U4 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 177 aa
19.3 kDa 		No 0
ANK2-014
ENSP00000425775
ENST00000511380
D6RIY9 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 112 aa
11.9 kDa 		No 0
ANK2-015
ENSP00000421059
ENST00000515034
D6RHC5 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 65 aa
6.9 kDa 		No 0
ANK2-022
ENSP00000426994
ENST00000504415
H0YAG3 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 187 aa
21.8 kDa 		No 0
ANK2-023
ENSP00000422888
ENST00000506344
H0Y933 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 197 aa
22 kDa 		No 0
ANK2-024
ENSP00000422486
ENST00000514167
H0Y8X8 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
8.9 kDa 		No 0
ANK2-026
ENSP00000264366
ENST00000264366
I6L894 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 3924 aa
430.3 kDa 		No 0
ANK2-027
ENSP00000489091
ENST00000634436
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 1195 aa
128.7 kDa 		No 0
ANK2-201
ENSP00000482888
ENST00000612754
A0A087WZU3 [Direct mapping]
Ankyrin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 180 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.