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NKD2

CANCER ATLAS

Gene description

 Naked cuticle homolog 2 (Drosophila)

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049463

GENE INFORMATION

Gene name

 NKD2 (HGNC Symbol)

Synonyms

 Naked2

Description

 Naked cuticle homolog 2 (Drosophila) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Chromosome

 5

Cytoband

 p15.33

Chromosome location (bp)

 1008829 - 1038943

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145506 (version 83.38)

Entrez gene

 85409

UniProt

 Q969F2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q969F2

Antibodypedia

 NKD2 antibodies

PROTEIN BROWSER
NKD2-001
NKD2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKD2-001
ENSP00000296849
ENST00000296849
Q969F2 [Direct mapping]
Protein naked cuticle homolog 2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006887 [exocytosis]
GO:0010954 [positive regulation of protein processing]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019838 [growth factor binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0048210 [Golgi vesicle fusion to target membrane]
GO:0071944 [cell periphery]
GO:0072661 [protein targeting to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 451 aa
50.1 kDa 		No 0
NKD2-002
ENSP00000274150
ENST00000274150
Q969F2 [Direct mapping]
Protein naked cuticle homolog 2
Show all
Predicted intracellular proteins
Show all
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0006887 [exocytosis]
GO:0010954 [positive regulation of protein processing]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016055 [Wnt signaling pathway]
GO:0016323 [basolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0019838 [growth factor binding]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0048210 [Golgi vesicle fusion to target membrane]
GO:0071944 [cell periphery]
GO:0072661 [protein targeting to plasma membrane]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 311 aa
34.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.