Tissue expression of NKD2 - Summary - The Human Protein Atlas

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NKD2

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NKD2
Gene description	Naked cuticle homolog 2 (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung, skin)
GTEx:	Tissue enhanced (lung)
FANTOM5:	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA049463
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung, skin)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)

GENE INFORMATION
Gene name	NKD2 (HGNC Symbol)
Synonyms	Naked2
Description	Naked cuticle homolog 2 (Drosophila) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	1008829 - 1038943
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145506 (version 83.38)
Entrez gene	85409
UniProt	Q969F2 (UniProt - Evidence at protein level)
neXtProt	NX_Q969F2
Antibodypedia	NKD2 antibodies

PROTEIN BROWSER

NKD2-001	NKD2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NKD2-001 ENSP00000296849 ENST00000296849	Q969F2 [Direct mapping] Protein naked cuticle homolog 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006887 [exocytosis] GO:0010954 [positive regulation of protein processing] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0019838 [growth factor binding] GO:0031410 [cytoplasmic vesicle] GO:0031625 [ubiquitin protein ligase binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048210 [Golgi vesicle fusion to target membrane] GO:0071944 [cell periphery] GO:0072661 [protein targeting to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	451 aa 50.1 kDa	No	0
NKD2-002 ENSP00000274150 ENST00000274150	Q969F2 [Direct mapping] Protein naked cuticle homolog 2 Show all	Predicted intracellular proteins Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0006887 [exocytosis] GO:0010954 [positive regulation of protein processing] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016055 [Wnt signaling pathway] GO:0016323 [basolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0019838 [growth factor binding] GO:0031410 [cytoplasmic vesicle] GO:0031625 [ubiquitin protein ligase binding] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0048210 [Golgi vesicle fusion to target membrane] GO:0071944 [cell periphery] GO:0072661 [protein targeting to plasma membrane] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	311 aa 34.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.