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RASA1

GENERAL INFORMATION

Gene name

 RASA1

Gene description

 RAS p21 protein activator (GTPase activating protein) 1

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in placenta and subsets of cells in fallopian tube.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification. Pending retesting.

Reliability score

 Supported based on 3 antibodies.
HPA036393 , HPA064556 , CAB007789
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

 RASA1 (HGNC Symbol)

Synonyms

 CM-AVM, GAP, p120GAP, p120RASGAP, RASA

Description

 RAS p21 protein activator (GTPase activating protein) 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]

Chromosome

 5

Cytoband

 q14.3

Chromosome location (bp)

 87267888 - 87391931

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145715 (version 83.38)

Entrez gene

 5921

UniProt

 P20936 (UniProt - Evidence at protein level)

neXtProt

 NX_P20936

Antibodypedia

 RASA1 antibodies

PROTEIN BROWSER
RASA1-001
RASA1-002
RASA1-003
RASA1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASA1-001
ENSP00000274376
ENST00000274376
P20936 [Direct mapping]
Ras GTPase-activating protein 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000281 [mitotic cytokinesis]
GO:0001570 [vasculogenesis]
GO:0001726 [ruffle]
GO:0001948 [glycoprotein binding]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0005096 [GTPase activator activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0019870 [potassium channel inhibitor activity]
GO:0030833 [regulation of actin filament polymerization]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0051020 [GTPase binding]
GO:0051252 [regulation of RNA metabolic process]
Show all
 1047 aa
116.4 kDa 		No 0
RASA1-002
ENSP00000411221
ENST00000456692
P20936 [Direct mapping]
Ras GTPase-activating protein 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000281 [mitotic cytokinesis]
GO:0001570 [vasculogenesis]
GO:0001948 [glycoprotein binding]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0005096 [GTPase activator activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0019870 [potassium channel inhibitor activity]
GO:0030833 [regulation of actin filament polymerization]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0051020 [GTPase binding]
GO:0051252 [regulation of RNA metabolic process]
Show all
 870 aa
100.4 kDa 		No 0
RASA1-003
ENSP00000420905
ENST00000506290
E9PGC0 [Direct mapping]
Ras GTPase-activating protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007165 [signal transduction]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0046580 [negative regulation of Ras protein signal transduction]
Show all
 881 aa
101.8 kDa 		No 0
RASA1-004
ENSP00000422008
ENST00000512763
P20936 [Direct mapping]
Ras GTPase-activating protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000281 [mitotic cytokinesis]
GO:0001570 [vasculogenesis]
GO:0001948 [glycoprotein binding]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0005096 [GTPase activator activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007162 [negative regulation of cell adhesion]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008360 [regulation of cell shape]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009790 [embryo development]
GO:0019870 [potassium channel inhibitor activity]
GO:0030833 [regulation of actin filament polymerization]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0051020 [GTPase binding]
GO:0051252 [regulation of RNA metabolic process]
Show all
 880 aa
101.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.