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ATG12

CANCER ATLAS

Gene description

 Autophagy related 12

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB013272

GENE INFORMATION

Gene name

 ATG12 (HGNC Symbol)

Synonyms

 APG12, APG12L

Description

 Autophagy related 12 (HGNC Symbol)

Entrez gene summary

 Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 q22.3

Chromosome location (bp)

 115828200 - 115841858

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145782 (version 83.38)

Entrez gene

 9140

UniProt

 O94817 (UniProt - Evidence at protein level)

neXtProt

 NX_O94817

Antibodypedia

 ATG12 antibodies

PROTEIN BROWSER
ATG12-001
ATG12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG12-001
ENSP00000425107
ENST00000509910
O94817 [Direct mapping]
Ubiquitin-like protein ATG12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0043234 [protein complex]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
Show all
 140 aa
15.1 kDa 		No 0
ATG12-003
ENSP00000425164
ENST00000500945
O94817 [Direct mapping]
Ubiquitin-like protein ATG12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
Show all
 74 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.