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ATG12

GENERAL INFORMATION

Gene name

 ATG12

Gene description

 Autophagy related 12

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
CAB013272
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Cerebellum
N/A
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATG12 (HGNC Symbol)

Synonyms

 APG12, APG12L

Description

 Autophagy related 12 (HGNC Symbol)

Entrez gene summary

 Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 q22.3

Chromosome location (bp)

 115828200 - 115841858

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145782 (version 83.38)

Entrez gene

 9140

UniProt

 O94817 (UniProt - Evidence at protein level)

neXtProt

 NX_O94817

Antibodypedia

 ATG12 antibodies

PROTEIN BROWSER
ATG12-001
ATG12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG12-001
ENSP00000425107
ENST00000509910
O94817 [Direct mapping]
Ubiquitin-like protein ATG12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0043234 [protein complex]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
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 140 aa
15.1 kDa 		No 0
ATG12-003
ENSP00000425164
ENST00000500945
O94817 [Direct mapping]
Ubiquitin-like protein ATG12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016236 [macroautophagy]
GO:0019776 [Atg8 ligase activity]
GO:0030670 [phagocytic vesicle membrane]
GO:0032480 [negative regulation of type I interferon production]
GO:0034045 [pre-autophagosomal structure membrane]
GO:0034274 [Atg12-Atg5-Atg16 complex]
GO:0044804 [nucleophagy]
GO:0045087 [innate immune response]
Show all
 74 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.