Cell atlas - ADAMTS19 - The Human Protein Atlas

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ADAMTS19

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Midbody
	Vesicles

Human cell
	Microtubules
	Vesicles

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GENERAL INFORMATION
Gene name	ADAMTS19
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 19
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the midbody & vesicles.
RNA cell category	Group enriched (SH-SY5Y, MCF7)
Protein evidence	Evidence at transcript level
Main location	Localized to the Vesicles (approved), Midbody (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058438
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SH-SY5Y, MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the midbody & vesicles.

Main location

Vesicles (approved), Midbody (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058438	HEK 293	No staining
	HPA058438	MCF7	Vesicles
	HPA058438	MCF7	Midbody	Intensity	Intensity
	HPA058438	U-2 OS	No staining

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition

GENE INFORMATION
Gene name	ADAMTS19
Synonyms
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q23.3
Chromosome location (bp)	129460265 - 129738683
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000145808 (version 83.38)
Entrez gene	171019
UniProt	Q8TE59 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TE59
Antibodypedia	ADAMTS19 antibodies

PROTEIN BROWSER

ADAMTS19-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS19-001 ENSP00000274487 ENST00000274487	Q8TE59 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 19 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1207 aa 134 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.