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GFRA3

CANCER ATLAS

Gene description

 GDNF family receptor alpha 3

Protein class

 Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020731

GENE INFORMATION

Gene name

 GFRA3 (HGNC Symbol)

Synonyms

 GFRa-3

Description

 GDNF family receptor alpha 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138252379 - 138274671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146013 (version 83.38)

Entrez gene

 2676

UniProt

 O60609 (UniProt - Evidence at protein level)

neXtProt

 NX_O60609

Antibodypedia

 GFRA3 antibodies

PROTEIN BROWSER
GFRA3-001
GFRA3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GFRA3-001
ENSP00000274721
ENST00000274721
O60609 [Direct mapping]
GDNF family receptor alpha-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001764 [neuron migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0008046 [axon guidance receptor activity]
GO:0009897 [external side of plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048485 [sympathetic nervous system development]
GO:0048666 [neuron development]
Show all
 400 aa
44.5 kDa 		Yes 1
GFRA3-002
ENSP00000367613
ENST00000378362
O60609 [Direct mapping]
GDNF family receptor alpha-3
K9J968 [Target identity:100%; Query identity:100%]
GDNF family receptor alpha-3 variant
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 369 aa
40.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.