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GFRA3

GENERAL INFORMATION

Gene name

 GFRA3

Gene description

 GDNF family receptor alpha 3

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA020731
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Seminal vesicle

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 GFRA3 (HGNC Symbol)

Synonyms

 GFRa-3

Description

 GDNF family receptor alpha 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138252379 - 138274671

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146013 (version 83.38)

Entrez gene

 2676

UniProt

 O60609 (UniProt - Evidence at protein level)

neXtProt

 NX_O60609

Antibodypedia

 GFRA3 antibodies

PROTEIN BROWSER
GFRA3-001
GFRA3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GFRA3-001
ENSP00000274721
ENST00000274721
O60609 [Direct mapping]
GDNF family receptor alpha-3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0001764 [neuron migration]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007411 [axon guidance]
GO:0007422 [peripheral nervous system development]
GO:0008046 [axon guidance receptor activity]
GO:0009897 [external side of plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048485 [sympathetic nervous system development]
GO:0048666 [neuron development]
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 400 aa
44.5 kDa 		Yes 1
GFRA3-002
ENSP00000367613
ENST00000378362
O60609 [Direct mapping]
GDNF family receptor alpha-3
K9J968 [Target identity:100%; Query identity:100%]
GDNF family receptor alpha-3 variant
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005102 [receptor binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007422 [peripheral nervous system development]
GO:0019898 [extrinsic component of membrane]
GO:0031225 [anchored component of membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 369 aa
40.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.