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SLC2A12

GENERAL INFORMATION

Gene name

 SLC2A12

Gene description

 Solute carrier family 2 (facilitated glucose transporter), member 12

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate)
GTEx:Mixed
FANTOM5:Tissue enhanced (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA031593
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina)

GENE INFORMATION

Gene name

 SLC2A12 (HGNC Symbol)

Synonyms

 GLUT12, GLUT8

Description

 Solute carrier family 2 (facilitated glucose transporter), member 12 (HGNC Symbol)

Entrez gene summary

 SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 133988697 - 134052636

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146411 (version 83.38)

Entrez gene

 154091

UniProt

 Q8TD20 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8TD20

Antibodypedia

 SLC2A12 antibodies

PROTEIN BROWSER
SLC2A12-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC2A12-001
ENSP00000275230
ENST00000275230
Q8TD20 [Direct mapping]
Solute carrier family 2, facilitated glucose transporter member 12
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
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GO:0005215 [transporter activity]
GO:0005351 [sugar:proton symporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0012505 [endomembrane system]
GO:0015758 [glucose transport]
GO:0015992 [proton transport]
GO:0016021 [integral component of membrane]
GO:0022857 [transmembrane transporter activity]
GO:0035428 [hexose transmembrane transport]
GO:0046323 [glucose import]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055085 [transmembrane transport]
GO:1904659 [glucose transmembrane transport]
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 617 aa
67 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.