Expression of SLC22A3 in cancer - Summary

CANCER ATLAS

Gene description

Solute carrier family 22 (organic cation transporter), member 3

Protein class

Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029750

GENE INFORMATION
Gene name	SLC22A3 (HGNC Symbol)
Synonyms	EMT, OCT3
Description	Solute carrier family 22 (organic cation transporter), member 3 (HGNC Symbol)
Entrez gene summary	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q25.3
Chromosome location (bp)	160348268 - 160452581
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146477 (version 83.38)
Entrez gene	6581
UniProt	O75751 (UniProt - Evidence at protein level)
neXtProt	NX_O75751
Antibodypedia	SLC22A3 antibodies

PROTEIN BROWSER

SLC22A3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC22A3-001 ENSP00000275300 ENST00000275300	O75751 [Direct mapping] Solute carrier family 22 member 3 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005329 [dopamine transmembrane transporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006855 [drug transmembrane transport] GO:0015075 [ion transmembrane transporter activity] GO:0015101 [organic cation transmembrane transporter activity] GO:0015651 [quaternary ammonium group transmembrane transporter activity] GO:0015695 [organic cation transport] GO:0015697 [quaternary ammonium group transport] GO:0015844 [monoamine transport] GO:0015872 [dopamine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019534 [toxin transporter activity] GO:0032098 [regulation of appetite] GO:0034220 [ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0051608 [histamine transport] GO:0051615 [histamine uptake] GO:0055085 [transmembrane transport] GO:0072488 [ammonium transmembrane transport] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1901998 [toxin transport] Show all	556 aa 61.3 kDa	No	>9