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SLC22A3

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GENERAL INFORMATION

Gene name

 SLC22A3

Gene description

 Solute carrier family 22 (organic cation transporter), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (A549, HeLa, Hep G2, RPTEC TERT1)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved), Cytosol (approved)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA029750
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, HeLa, Hep G2, RPTEC TERT1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.

Main location

 Vesicles (approved), Cytosol (approved)

Additional location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA029750 A549 Vesicles
Cytosol
HPA029750 HeLa Nucleoplasm
Vesicles
Cytosol
HPA029750 U-2 OS Cytosol

GENE INFORMATION

Gene name

 SLC22A3 (HGNC Symbol)

Synonyms

 EMT, OCT3

Description

 Solute carrier family 22 (organic cation transporter), member 3 (HGNC Symbol)

Entrez gene summary

 Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q25.3

Chromosome location (bp)

 160348268 - 160452581

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146477 (version 83.38)

Entrez gene

 6581

UniProt

 O75751 (UniProt - Evidence at protein level)

neXtProt

 NX_O75751

Antibodypedia

 SLC22A3 antibodies

PROTEIN BROWSER
SLC22A3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC22A3-001
ENSP00000275300
ENST00000275300
O75751 [Direct mapping]
Solute carrier family 22 member 3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005329 [dopamine transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006855 [drug transmembrane transport]
GO:0015075 [ion transmembrane transporter activity]
GO:0015101 [organic cation transmembrane transporter activity]
GO:0015651 [quaternary ammonium group transmembrane transporter activity]
GO:0015695 [organic cation transport]
GO:0015697 [quaternary ammonium group transport]
GO:0015844 [monoamine transport]
GO:0015872 [dopamine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019534 [toxin transporter activity]
GO:0032098 [regulation of appetite]
GO:0034220 [ion transmembrane transport]
GO:0044281 [small molecule metabolic process]
GO:0051608 [histamine transport]
GO:0051615 [histamine uptake]
GO:0055085 [transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901998 [toxin transport]
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 556 aa
61.3 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.