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SH3KBP1

GENERAL INFORMATION

Gene name

 SH3KBP1

Gene description

 SH3-domain kinase binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression, most abundant in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA003351 , HPA003355 , CAB021892
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Urinary bladder

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin05101520RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100120Tags Per Million

GENE INFORMATION

Gene name

 SH3KBP1 (HGNC Symbol)

Synonyms

 CIN85

Description

 SH3-domain kinase binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 p22.12

Chromosome location (bp)

 19533975 - 19887601

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147010 (version 83.38)

Entrez gene

 30011

UniProt

 Q96B97 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96B97

Antibodypedia

 SH3KBP1 antibodies

PROTEIN BROWSER
SH3KBP1-001
SH3KBP1-002
SH3KBP1-003
SH3KBP1-004
SH3KBP1-005
SH3KBP1-006
SH3KBP1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SH3KBP1-001
ENSP00000380921
ENST00000397821
Q96B97 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
Q5JPT6 [Target identity:100%; Query identity:100%]
GIG10; Migration-inducing gene 18 protein; cDNA, FLJ93821, Homo sapiens SH3-domain kinase binding protein 1 (SH3KBP1), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008360 [regulation of cell shape]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
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 665 aa
73.1 kDa 		No 0
SH3KBP1-002
ENSP00000369019
ENST00000379697
Q5VSN0 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 553 aa
61.4 kDa 		No 0
SH3KBP1-003
ENSP00000369020
ENST00000379698
Q96B97 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008360 [regulation of cell shape]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
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 628 aa
68.5 kDa 		No 0
SH3KBP1-004
ENSP00000369049
ENST00000379726
Q5JPT2 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 645 aa
70.4 kDa 		No 0
SH3KBP1-005
ENSP00000388766
ENST00000432234
Q5JPT1 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 208 aa
22.8 kDa 		No 0
SH3KBP1-006
ENSP00000409292
ENST00000431164
Q5JPT3 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 149 aa
16.4 kDa 		No 0
SH3KBP1-008
ENSP00000369039
ENST00000379716
Q96B97 [Direct mapping]
SH3 domain-containing kinase-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0007010 [cytoskeleton organization]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007267 [cell-cell signaling]
GO:0008360 [regulation of cell shape]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
Show all
 427 aa
46.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.