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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MSN

Gene description

Moesin

Protein class

Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most cell types. Highly abundant in lymphoid cells and endothelial cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Supported based on 5 antibodies.
HPA000263 , HPA011135 , HPA011227 , CAB010898 , CAB047338
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

MSN

Synonyms

Description

Moesin (HGNC Symbol)

Entrez gene summary

Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q12

Chromosome location (bp)

65588377 - 65741931

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147065 (version 83.38)

Entrez gene

4478

UniProt

P26038 (UniProt - Evidence at protein level)

neXtProt

NX_P26038

Antibodypedia

MSN antibodies

PROTEIN BROWSER

MSN-001
MSN-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSN-001
ENSP00000353408
ENST00000360270
P26038 [Direct mapping]
Moesin
V9HWC0 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 70; Moesin, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001931 [uropod]
GO:0003725 [double-stranded RNA binding]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005902 [microvillus]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007159 [leukocyte cell-cell adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008360 [regulation of cell shape]
GO:0008361 [regulation of cell size]
GO:0010628 [positive regulation of gene expression]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019901 [protein kinase binding]
GO:0022612 [gland morphogenesis]
GO:0022614 [membrane to membrane docking]
GO:0030175 [filopodium]
GO:0031143 [pseudopodium]
GO:0031528 [microvillus membrane]
GO:0031982 [vesicle]
GO:0043209 [myelin sheath]
GO:0045177 [apical part of cell]
GO:0045198 [establishment of epithelial cell apical/basal polarity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050839 [cell adhesion molecule binding]
GO:0050900 [leukocyte migration]
GO:0061028 [establishment of endothelial barrier]
GO:0070062 [extracellular exosome]
GO:0071394 [cellular response to testosterone stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:0071944 [cell periphery]
GO:0072562 [blood microparticle]
GO:1902115 [regulation of organelle assembly]
GO:1902966 [positive regulation of protein localization to early endosome]
GO:1903364 [positive regulation of cellular protein catabolic process]
GO:2000401 [regulation of lymphocyte migration]
GO:2000643 [positive regulation of early endosome to late endosome transport]
Show all
577 aa
67.8 kDa
No 0
MSN-003
ENSP00000477441
ENST00000609672
V9GZ54 [Direct mapping]
Moesin
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
Show all
103 aa
12.1 kDa
No 0

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