Expression of LPAR4 in cancer - Summary

CANCER ATLAS

Gene description

Lysophosphatidic acid receptor 4

Protein class

G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Urothelial cancer

STAINING SUMMARY

HPA054951	HPA055571

GENE INFORMATION
Gene name	LPAR4 (HGNC Symbol)
Synonyms	GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9
Description	Lysophosphatidic acid receptor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysophosphatidic acid receptor family. It may also be related to the P2Y receptors, a family of receptors that bind purine and pyrimidine nucleotides and are coupled to G proteins. The encoded protein may play a role in monocytic differentiation. [provided by RefSeq, Feb 2009]
Chromosome	X
Cytoband	q21.1
Chromosome location (bp)	78747709 - 78757094
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147145 (version 83.38)
Entrez gene	2846
UniProt	Q99677 (UniProt - Evidence at protein level)
neXtProt	NX_Q99677
Antibodypedia	LPAR4 antibodies

PROTEIN BROWSER

LPAR4-001	LPAR4-002	LPAR4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR4-001 ENSP00000408205 ENST00000435339	Q99677 [Direct mapping] Lysophosphatidic acid receptor 4 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] GO:0035727 [lysophosphatidic acid binding] GO:0070915 [lysophosphatidic acid receptor activity] Show all	370 aa 41.9 kDa	No	7
LPAR4-002 ENSP00000476460 ENST00000514744	V9GY74 [Direct mapping] Lysophosphatidic acid receptor 4 Show all	Predicted intracellular proteins Show all		45 aa 5.1 kDa	No	0
LPAR4-201 ENSP00000478261 ENST00000614823	Q99677 [Direct mapping] Lysophosphatidic acid receptor 4 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008289 [lipid binding] GO:0016021 [integral component of membrane] Show all	370 aa 41.9 kDa	No	7