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AWAT2

CANCER ATLAS

Gene description

 Acyl-CoA wax alcohol acyltransferase 2

Protein class

 Enzymes, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA062748

GENE INFORMATION

Gene name

 AWAT2 (HGNC Symbol)

Synonyms

 DGAT2L4, MFAT

Description

 Acyl-CoA wax alcohol acyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70040542 - 70049938

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147160 (version 83.38)

Entrez gene

 158835

UniProt

 Q6E213 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6E213

Antibodypedia

 AWAT2 antibodies

PROTEIN BROWSER
AWAT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AWAT2-001
ENSP00000421172
ENST00000276101
Q6E213 [Direct mapping]
Acyl-CoA wax alcohol acyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0010025 [wax biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0042572 [retinol metabolic process]
GO:0047196 [long-chain-alcohol O-fatty-acyltransferase activity]
GO:0050252 [retinol O-fatty-acyltransferase activity]
Show all
 333 aa
38.1 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.