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AWAT2

GENERAL INFORMATION

Gene name

 AWAT2

Gene description

 Acyl-CoA wax alcohol acyltransferase 2

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (breast, skin)
GTEx:Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in sebaceous glands.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA062748
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (breast, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skin)

GENE INFORMATION

Gene name

 AWAT2 (HGNC Symbol)

Synonyms

 DGAT2L4, MFAT

Description

 Acyl-CoA wax alcohol acyltransferase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. [provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70040542 - 70049938

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147160 (version 83.38)

Entrez gene

 158835

UniProt

 Q6E213 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6E213

Antibodypedia

 AWAT2 antibodies

PROTEIN BROWSER
AWAT2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AWAT2-001
ENSP00000421172
ENST00000276101
Q6E213 [Direct mapping]
Acyl-CoA wax alcohol acyltransferase 2
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Enzymes
   ENZYME proteins
   Transferases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
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GO:0005789 [endoplasmic reticulum membrane]
GO:0010025 [wax biosynthetic process]
GO:0016021 [integral component of membrane]
GO:0016747 [transferase activity, transferring acyl groups other than amino-acyl groups]
GO:0042572 [retinol metabolic process]
GO:0047196 [long-chain-alcohol O-fatty-acyltransferase activity]
GO:0050252 [retinol O-fatty-acyltransferase activity]
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 333 aa
38.1 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.