Cell atlas - HMBOX1 - The Human Protein Atlas

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HMBOX1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	HMBOX1
Gene description	Homeobox containing 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Nuclear bodies (validated), Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA055855 , HPA058586
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol & nuclear bodies.

Main location

Nucleoplasm (validated)

Additional location

Nuclear bodies (validated), Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
HPA055855	HeLa	Nucleoplasm
HPA055855	HeLa	Cytosol
HPA055855	U-2 OS	Nucleoplasm
HPA055855	U-2 OS	Nuclear bodies	Intensity
HPA055855	U-251 MG	Nucleoplasm
HPA055855	U-251 MG	Cytosol
HPA058586	HeLa	Nucleoplasm	Intensity
HPA058586	HeLa	Cytosol
HPA058586	U-2 OS	Nucleoplasm
		Nuclear bodies
		Cytosol

GENE INFORMATION
Gene name	HMBOX1 (HGNC Symbol)
Synonyms	FLJ21616, HNF1LA, HOT1, PBHNF
Description	Homeobox containing 1 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband
Chromosome location (bp)	28890394 - 29064764
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147421 (version 83.38)
Entrez gene	79618
UniProt	Q6NT76 (UniProt - Evidence at protein level)
neXtProt	NX_Q6NT76
Antibodypedia	HMBOX1 antibodies

PROTEIN BROWSER

HMBOX1-001	HMBOX1-002	HMBOX1-003	HMBOX1-005	HMBOX1-006	HMBOX1-008	HMBOX1-014	HMBOX1-015	HMBOX1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMBOX1-001 ENSP00000380516 ENST00000397358	Q6NT76 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	420 aa 47.3 kDa	No	0
HMBOX1-002 ENSP00000287701 ENST00000287701	Q6NT76 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	420 aa 47.3 kDa	No	0
HMBOX1-003 ENSP00000452827 ENST00000523613	H0YKJ1 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	396 aa 44.5 kDa	No	0
HMBOX1-005 ENSP00000430059 ENST00000519047	E5RGZ2 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	386 aa 43.7 kDa	No	0
HMBOX1-006 ENSP00000430110 ENST00000524238	Q6NT76 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	443 aa 49.9 kDa	No	0
HMBOX1-008 ENSP00000429767 ENST00000519662	E5RHH9 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	118 aa 13 kDa	No	0
HMBOX1-014 ENSP00000453211 ENST00000558662	Q6NT76 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	405 aa 46 kDa	No	0
HMBOX1-015 ENSP00000453185 ENST00000560599	H0YLF2 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	365 aa 41.1 kDa	No	0
HMBOX1-017 ENSP00000475196 ENST00000355231	E5RGZ2 [Direct mapping] Homeobox-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	386 aa 43.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.