Fields »
ABOUT
HELP
BLOG
ERLIN2

CANCER ATLAS

Gene description

 ER lipid raft associated 2

Protein class

 Disease related genes, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA002025
CAB014894

GENE INFORMATION

Gene name

 ERLIN2 (HGNC Symbol)

Synonyms

 C8orf2, Erlin-2, NET32, SPFH2, SPG18

Description

 ER lipid raft associated 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 8

Cytoband

 p11.23

Chromosome location (bp)

 37736599 - 37759101

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147475 (version 83.38)

Entrez gene

 11160

UniProt

 O94905 (UniProt - Evidence at protein level)

neXtProt

 NX_O94905

Antibodypedia

 ERLIN2 antibodies

PROTEIN BROWSER
ERLIN2-001
ERLIN2-002
ERLIN2-006
ERLIN2-007
ERLIN2-008
ERLIN2-009
ERLIN2-010
ERLIN2-014
ERLIN2-015

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERLIN2-001
ENSP00000276461
ENST00000276461
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 339 aa
37.8 kDa 		Yes 0
ERLIN2-002
ENSP00000380405
ENST00000397228
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 152 aa
16.8 kDa 		Yes 0
ERLIN2-006
ENSP00000429903
ENST00000523887
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 206 aa
22.9 kDa 		Yes 0
ERLIN2-007
ENSP00000427847
ENST00000518586
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 206 aa
22.9 kDa 		Yes 0
ERLIN2-008
ENSP00000335220
ENST00000335171
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 152 aa
16.8 kDa 		Yes 0
ERLIN2-009
ENSP00000429621
ENST00000521644
E5RHW4 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
Show all
 338 aa
37.7 kDa 		Yes 0
ERLIN2-010
ENSP00000428112
ENST00000519638
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 339 aa
37.8 kDa 		Yes 0
ERLIN2-014
ENSP00000429229
ENST00000518526
E5RJ09 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 197 aa
22.3 kDa 		Yes 0
ERLIN2-015
ENSP00000473292
ENST00000523107
O94905 [Direct mapping]
Erlin-2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0008203 [cholesterol metabolic process]
GO:0015485 [cholesterol binding]
GO:0016021 [integral component of membrane]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032933 [SREBP signaling pathway]
GO:0043234 [protein complex]
GO:0045121 [membrane raft]
GO:0045541 [negative regulation of cholesterol biosynthetic process]
GO:0045717 [negative regulation of fatty acid biosynthetic process]
GO:0070062 [extracellular exosome]
Show all
 206 aa
22.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.