Cell atlas - ERLIN2 - The Human Protein Atlas

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ERLIN2

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	ERLIN2
Gene description	ER lipid raft associated 2
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA002025
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002025	A-431	Endoplasmic reticulum
	HPA002025	U-2 OS	Plasma membrane
	HPA002025	U-2 OS	Cytosol
	HPA002025	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	ERLIN2 (HGNC Symbol)
Synonyms	C8orf2, Erlin-2, NET32, SPFH2, SPG18
Description	ER lipid raft associated 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	37736599 - 37759101
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147475 (version 83.38)
Entrez gene	11160
UniProt	O94905 (UniProt - Evidence at protein level)
neXtProt	NX_O94905
Antibodypedia	ERLIN2 antibodies

PROTEIN BROWSER

ERLIN2-001	ERLIN2-002	ERLIN2-006	ERLIN2-007	ERLIN2-008	ERLIN2-009	ERLIN2-010	ERLIN2-014	ERLIN2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERLIN2-001 ENSP00000276461 ENST00000276461	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	339 aa 37.8 kDa	Yes	0
ERLIN2-002 ENSP00000380405 ENST00000397228	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	152 aa 16.8 kDa	Yes	0
ERLIN2-006 ENSP00000429903 ENST00000523887	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	206 aa 22.9 kDa	Yes	0
ERLIN2-007 ENSP00000427847 ENST00000518586	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	206 aa 22.9 kDa	Yes	0
ERLIN2-008 ENSP00000335220 ENST00000335171	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	152 aa 16.8 kDa	Yes	0
ERLIN2-009 ENSP00000429621 ENST00000521644	E5RHW4 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005886 [plasma membrane] Show all	338 aa 37.7 kDa	Yes	0
ERLIN2-010 ENSP00000428112 ENST00000519638	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	339 aa 37.8 kDa	Yes	0
ERLIN2-014 ENSP00000429229 ENST00000518526	E5RJ09 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		197 aa 22.3 kDa	Yes	0
ERLIN2-015 ENSP00000473292 ENST00000523107	O94905 [Direct mapping] Erlin-2 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0032933 [SREBP signaling pathway] GO:0043234 [protein complex] GO:0045121 [membrane raft] GO:0045541 [negative regulation of cholesterol biosynthetic process] GO:0045717 [negative regulation of fatty acid biosynthetic process] GO:0070062 [extracellular exosome] Show all	206 aa 22.9 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.