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TACC1

GENERAL INFORMATION

Gene name

 TACC1

Gene description

 Transforming, acidic coiled-coil containing protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic and nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA024702 , CAB017041
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TACC1

Synonyms

Description

 Transforming, acidic coiled-coil containing protein 1 (HGNC Symbol)

Entrez gene summary

 This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Chromosome

 8

Cytoband

 p11.22

Chromosome location (bp)

 38728186 - 38853028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147526 (version 83.38)

Entrez gene

 6867

UniProt

 O75410 (UniProt - Evidence at protein level)

neXtProt

 NX_O75410

Antibodypedia

 TACC1 antibodies

PROTEIN BROWSER
«
TACC1-001
TACC1-002
TACC1-003
TACC1-004
TACC1-006
TACC1-007
TACC1-008
TACC1-014
TACC1-015
TACC1-016
TACC1-018
TACC1-020
TACC1-021
TACC1-026
TACC1-029
TACC1-031
TACC1-033
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TACC1-001
ENSP00000321703
ENST00000317827
O75410 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0019904 [protein domain specific binding]
GO:0021987 [cerebral cortex development]
GO:0022008 [neurogenesis]
GO:0022027 [interkinetic nuclear migration]
GO:0032886 [regulation of microtubule-based process]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051301 [cell division]
Show all
 805 aa
87.8 kDa 		No 0
TACC1-002
ENSP00000428450
ENST00000520615
O75410 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051301 [cell division]
Show all
 610 aa
67.1 kDa 		No 0
TACC1-003
ENSP00000276520
ENST00000276520
O75410 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051301 [cell division]
Show all
 395 aa
44 kDa 		No 0
TACC1-004
ENSP00000428687
ENST00000519416
E7ET87 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005737 [cytoplasm]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 609 aa
67 kDa 		No 0
TACC1-006
ENSP00000428706
ENST00000518415
O75410 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0007049 [cell cycle]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
GO:0051301 [cell division]
Show all
 731 aa
79.9 kDa 		No 0
TACC1-007
ENSP00000428466
ENST00000521642
A0A0C4DGD3 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 133 aa
14.2 kDa 		No 0
TACC1-008
ENSP00000428949
ENST00000521050
A0A0C4DGD5 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 145 aa
15.6 kDa 		No 0
TACC1-014
ENSP00000430306
ENST00000518809
H0YBT8 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 454 aa
50.4 kDa 		No 0
TACC1-015
ENSP00000430959
ENST00000520973
E7EVI4 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005737 [cytoplasm]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 581 aa
63.9 kDa 		No 0
TACC1-016
ENSP00000429418
ENST00000520611
B4E3H6 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1; cDNA FLJ52297, highly similar to Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 242 aa
27.6 kDa 		No 0
TACC1-018
ENSP00000430562
ENST00000524354
E5RJG6 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 129 aa
13.7 kDa 		No 0
TACC1-020
ENSP00000430819
ENST00000521528
E5RI10 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 30 aa
3 kDa 		No 0
TACC1-021
ENSP00000429330
ENST00000524193
E5RIP3 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 61 aa
6.4 kDa 		No 0
TACC1-026
ENSP00000473342
ENST00000520340
R4GMT7 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005737 [cytoplasm]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 580 aa
62.4 kDa 		No 0
TACC1-029
ENSP00000428175
ENST00000521935
E5RJU4 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 138 aa
14.8 kDa 		No 0
TACC1-031
ENSP00000430355
ENST00000522904
E5RFM9 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0005737 [cytoplasm]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0021987 [cerebral cortex development]
GO:0045111 [intermediate filament cytoskeleton]
Show all
 557 aa
59.3 kDa 		No 0
TACC1-033
ENSP00000428253
ENST00000521866
H0YAY0 [Direct mapping]
Transforming acidic coiled-coil-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0008283 [cell proliferation]
GO:0021987 [cerebral cortex development]
Show all
 562 aa
62.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.