Fields »
ABOUT
HELP
BLOG
GINS4

GENERAL INFORMATION

Gene name

 GINS4

Gene description

 GINS complex subunit 4 (Sld5 homolog)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (testis)
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA024663 , HPA026580
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 GINS4 (HGNC Symbol)

Synonyms

 MGC14799, SLD5

Description

 GINS complex subunit 4 (Sld5 homolog) (HGNC Symbol)

Entrez gene summary

 The yeast heterotetrameric GINS complex is made up of Sld5, Psf1 (GINS1; MIM 610608), Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]). See GINS1 for additional information about the GINS complex.[supplied by OMIM, Mar 2008]

Chromosome

 8

Cytoband

 p11.21

Chromosome location (bp)

 41529206 - 41545046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147536 (version 83.38)

Entrez gene

 84296

UniProt

 Q9BRT9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BRT9

Antibodypedia

 GINS4 antibodies

PROTEIN BROWSER
GINS4-001
GINS4-003
GINS4-004
GINS4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GINS4-001
ENSP00000429581
ENST00000520710
Q9BRT9 [Direct mapping]
DNA replication complex GINS protein SLD5 DNA replication complex GINS protein SLD5, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0000811 [GINS complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031298 [replication fork protection complex]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
Show all
 100 aa
11.8 kDa 		No 0
GINS4-003
ENSP00000428754
ENST00000518671
Q9BRT9 [Direct mapping]
DNA replication complex GINS protein SLD5 DNA replication complex GINS protein SLD5, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0000811 [GINS complex]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031298 [replication fork protection complex]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
Show all
 223 aa
26 kDa 		No 0
GINS4-004
ENSP00000428901
ENST00000523277
E5RFF9 [Direct mapping]
DNA replication complex GINS protein SLD5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000727 [double-strand break repair via break-induced replication]
GO:0000811 [GINS complex]
GO:0006270 [DNA replication initiation]
GO:0031298 [replication fork protection complex]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
Show all
 192 aa
22.7 kDa 		No 0
GINS4-201
ENSP00000276533
ENST00000276533
Q9BRT9 [Direct mapping]
DNA replication complex GINS protein SLD5 DNA replication complex GINS protein SLD5, N-terminally processed
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000727 [double-strand break repair via break-induced replication]
GO:0000811 [GINS complex]
GO:0001833 [inner cell mass cell proliferation]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006270 [DNA replication initiation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0031298 [replication fork protection complex]
GO:0032508 [DNA duplex unwinding]
GO:0043138 [3'-5' DNA helicase activity]
Show all
 223 aa
26 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.