Expression of ADHFE1 in cancer - Summary

CANCER ATLAS

Gene description

Alcohol dehydrogenase, iron containing, 1

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA023062

GENE INFORMATION
Gene name	ADHFE1 (HGNC Symbol)
Synonyms	ADHFe1, FLJ32430
Description	Alcohol dehydrogenase, iron containing, 1 (HGNC Symbol)
Entrez gene summary	The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q13.1
Chromosome location (bp)	66430185 - 66471601
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147576 (version 83.38)
Entrez gene	137872
UniProt	Q8IWW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWW8
Antibodypedia	ADHFE1 antibodies

PROTEIN BROWSER

ADHFE1-001	ADHFE1-004	ADHFE1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADHFE1-001 ENSP00000379865 ENST00000396623	Q8IWW8 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0015993 [molecular hydrogen transport] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047988 [hydroxyacid-oxoacid transhydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	467 aa 50.3 kDa	No	0
ADHFE1-004 ENSP00000407115 ENST00000415254	Q8IWW8 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0015993 [molecular hydrogen transport] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047988 [hydroxyacid-oxoacid transhydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	419 aa 45.1 kDa	No	0
ADHFE1-018 ENSP00000428055 ENST00000523113	E5RFL4 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	88 aa 9.5 kDa	No	0