Cell atlas - ADHFE1 - The Human Protein Atlas

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ADHFE1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	ADHFE1
Gene description	Alcohol dehydrogenase, iron containing, 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Cell line enhanced (RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA023062
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023062	A-431	Vesicles
	HPA023062	U-2 OS	Vesicles
	HPA023062	U-251 MG	Vesicles

GENE INFORMATION
Gene name	ADHFE1 (HGNC Symbol)
Synonyms	ADHFe1, FLJ32430
Description	Alcohol dehydrogenase, iron containing, 1 (HGNC Symbol)
Entrez gene summary	The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q13.1
Chromosome location (bp)	66430185 - 66471601
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147576 (version 83.38)
Entrez gene	137872
UniProt	Q8IWW8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWW8
Antibodypedia	ADHFE1 antibodies

PROTEIN BROWSER

ADHFE1-001	ADHFE1-004	ADHFE1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADHFE1-001 ENSP00000379865 ENST00000396623	Q8IWW8 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0015993 [molecular hydrogen transport] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047988 [hydroxyacid-oxoacid transhydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	467 aa 50.3 kDa	No	0
ADHFE1-004 ENSP00000407115 ENST00000415254	Q8IWW8 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006103 [2-oxoglutarate metabolic process] GO:0015993 [molecular hydrogen transport] GO:0016491 [oxidoreductase activity] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047988 [hydroxyacid-oxoacid transhydrogenase activity] GO:0055114 [oxidation-reduction process] Show all	419 aa 45.1 kDa	No	0
ADHFE1-018 ENSP00000428055 ENST00000523113	E5RFL4 [Direct mapping] Hydroxyacid-oxoacid transhydrogenase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016491 [oxidoreductase activity] GO:0046872 [metal ion binding] GO:0055114 [oxidation-reduction process] Show all	88 aa 9.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.