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PRDM14

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GENERAL INFORMATION

Gene name

 PRDM14

Gene description

 PR domain containing 14

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Cell line enriched (NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (uncertain)

DATA RELIABILITY

Reliability score

 Uncertain based on 1 antibody.
HPA057070
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (uncertain)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA057070 RH-30 Nucleoplasm
HPA057070 U-2 OS Nucleoplasm

GENE INFORMATION

Gene name

 PRDM14

Synonyms

Description

 PR domain containing 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

Chromosome

 8

Cytoband

 q13.3

Chromosome location (bp)

 70051651 - 70071693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147596 (version 83.38)

Entrez gene

 63978

UniProt

 Q9GZV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV8

Antibodypedia

 PRDM14 antibodies

PROTEIN BROWSER
PRDM14-001
PRDM14-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDM14-001
ENSP00000276594
ENST00000276594
Q9GZV8 [Direct mapping]
PR domain zinc finger protein 14
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0001708 [cell fate specification]
GO:0001827 [inner cell mass cell fate commitment]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007281 [germ cell development]
GO:0007566 [embryo implantation]
GO:0008168 [methyltransferase activity]
GO:0009566 [fertilization]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0030718 [germ-line stem cell population maintenance]
GO:0031490 [chromatin DNA binding]
GO:0034972 [histone H3-R26 methylation]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0044030 [regulation of DNA methylation]
GO:0046872 [metal ion binding]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0060817 [inactivation of paternal X chromosome]
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 571 aa
64.1 kDa 		No 0
PRDM14-002
ENSP00000408653
ENST00000426346
C9JMM8 [Direct mapping]
PR domain zinc finger protein 14
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 100 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.