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PRDM14

GENERAL INFORMATION

Gene name

 PRDM14

Gene description

 PR domain containing 14

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (testis)
GTEx:Not detected
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA019094
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 PRDM14

Synonyms

Description

 PR domain containing 14 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess histone methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast cancer. [provided by RefSeq, Dec 2011]

Chromosome

 8

Cytoband

 q13.3

Chromosome location (bp)

 70051651 - 70071693

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147596 (version 83.38)

Entrez gene

 63978

UniProt

 Q9GZV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZV8

Antibodypedia

 PRDM14 antibodies

PROTEIN BROWSER
PRDM14-001
PRDM14-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRDM14-001
ENSP00000276594
ENST00000276594
Q9GZV8 [Direct mapping]
PR domain zinc finger protein 14
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000902 [cell morphogenesis]
GO:0001708 [cell fate specification]
GO:0001827 [inner cell mass cell fate commitment]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007281 [germ cell development]
GO:0007566 [embryo implantation]
GO:0008168 [methyltransferase activity]
GO:0009566 [fertilization]
GO:0010468 [regulation of gene expression]
GO:0019827 [stem cell population maintenance]
GO:0030718 [germ-line stem cell population maintenance]
GO:0031490 [chromatin DNA binding]
GO:0034972 [histone H3-R26 methylation]
GO:0035019 [somatic stem cell population maintenance]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0040037 [negative regulation of fibroblast growth factor receptor signaling pathway]
GO:0044030 [regulation of DNA methylation]
GO:0046872 [metal ion binding]
GO:0048873 [homeostasis of number of cells within a tissue]
GO:0060817 [inactivation of paternal X chromosome]
Show all
 571 aa
64.1 kDa 		No 0
PRDM14-002
ENSP00000408653
ENST00000426346
C9JMM8 [Direct mapping]
PR domain zinc finger protein 14
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 100 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.