Expression of LRP12 in cancer - Summary

CANCER ATLAS

Gene description

Low density lipoprotein receptor-related protein 12

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017245

GENE INFORMATION
Gene name	LRP12 (HGNC Symbol)
Synonyms	FLJ12929, ST7
Description	Low density lipoprotein receptor-related protein 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	104489231 - 104589024
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147650 (version 83.38)
Entrez gene	29967
UniProt	Q9Y561 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y561
Antibodypedia	LRP12 antibodies

PROTEIN BROWSER

LRP12-001	LRP12-002	LRP12-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRP12-001 ENSP00000276654 ENST00000276654	Q9Y561 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	859 aa 95 kDa	Yes	1
LRP12-002 ENSP00000399148 ENST00000424843	Q9Y561 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	840 aa 93.1 kDa	Yes	1
LRP12-004 ENSP00000429305 ENST00000523007	E5RIW8 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	201 aa 22.6 kDa	No	1