Tissue expression of LRP12 - Summary - The Human Protein Atlas

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LRP12

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	LRP12
Gene description	Low density lipoprotein receptor-related protein 12
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Nuclear and cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA017245
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	LRP12 (HGNC Symbol)
Synonyms	FLJ12929, ST7
Description	Low density lipoprotein receptor-related protein 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	104489231 - 104589024
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147650 (version 83.38)
Entrez gene	29967
UniProt	Q9Y561 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y561
Antibodypedia	LRP12 antibodies

PROTEIN BROWSER

LRP12-001	LRP12-002	LRP12-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRP12-001 ENSP00000276654 ENST00000276654	Q9Y561 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	859 aa 95 kDa	Yes	1
LRP12-002 ENSP00000399148 ENST00000424843	Q9Y561 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005041 [low-density lipoprotein receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005905 [coated pit] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] Show all	840 aa 93.1 kDa	Yes	1
LRP12-004 ENSP00000429305 ENST00000523007	E5RIW8 [Direct mapping] Low-density lipoprotein receptor-related protein 12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	201 aa 22.6 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.