Expression of RSPO2 in cancer - Summary

CANCER ATLAS

Gene description

R-spondin 2

Protein class

Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024764	HPA053068	CAB025900

GENE INFORMATION
Gene name	RSPO2 (HGNC Symbol)
Synonyms	MGC35555
Description	R-spondin 2 (HGNC Symbol)
Entrez gene summary	R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	q23.1
Chromosome location (bp)	107899316 - 108083648
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147655 (version 83.38)
Entrez gene	340419
UniProt	Q6UXX9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXX9
Antibodypedia	RSPO2 antibodies

PROTEIN BROWSER

RSPO2-001	RSPO2-002	RSPO2-003	RSPO2-004	RSPO2-005	RSPO2-006	RSPO2-007	RSPO2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RSPO2-001 ENSP00000276659 ENST00000276659	Q6UXX9 [Direct mapping] R-spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001649 [osteoblast differentiation] GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008201 [heparin binding] GO:0009986 [cell surface] GO:0016055 [Wnt signaling pathway] GO:0030282 [bone mineralization] GO:0035115 [embryonic forelimb morphogenesis] GO:0035116 [embryonic hindlimb morphogenesis] GO:0042489 [negative regulation of odontogenesis of dentin-containing tooth] GO:0060437 [lung growth] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060535 [trachea cartilage morphogenesis] GO:0071542 [dopaminergic neuron differentiation] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	243 aa 28.3 kDa	Yes	0
RSPO2-002 ENSP00000427937 ENST00000517781	Q6UXX9 [Direct mapping] R-spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	179 aa 21 kDa	Yes	0
RSPO2-003 ENSP00000428940 ENST00000517939	Q6UXX9 [Direct mapping] R-spondin-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0016055 [Wnt signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	176 aa 20.4 kDa	No	0
RSPO2-004 ENSP00000430973 ENST00000522333	E5RGU9 [Direct mapping] R-spondin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005615 [extracellular space] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	77 aa 9.1 kDa	Yes	0
RSPO2-005 ENSP00000430010 ENST00000521956	E5RH25 [Direct mapping] R-spondin-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005615 [extracellular space] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	121 aa 14.2 kDa	Yes	0
RSPO2-006 ENSP00000429159 ENST00000520026	E5RJA2 [Direct mapping] R-spondin-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005615 [extracellular space] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	89 aa 10.2 kDa	No	0
RSPO2-007 ENSP00000430485 ENST00000521757	E5RJU7 [Direct mapping] R-spondin-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005615 [extracellular space] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	89 aa 10.2 kDa	No	0
RSPO2-008 ENSP00000428614 ENST00000521502	E5RHC3 [Direct mapping] R-spondin-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0001664 [G-protein coupled receptor binding] GO:0005615 [extracellular space] GO:0090263 [positive regulation of canonical Wnt signaling pathway] Show all	168 aa 19.6 kDa	No	0