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Gene name

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In atlas

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Searches

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Detectable

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RSPO2
  • TISSUE

  • CELL

  • CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RSPO2

Gene description

R-spondin 2

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta, cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Tissue enhanced (retina, brain)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues including exocrine glandular cells, cells in tubules and ovarian follicle cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

Approved based on 3 antibodies.
HPA024764 , HPA053068 , CAB025900
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta, cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin051015202530TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (retina, brain)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina010203040Tags Per Million

GENE INFORMATION

Gene name

RSPO2 (HGNC Symbol)

Synonyms

MGC35555

Description

R-spondin 2 (HGNC Symbol)

Entrez gene summary

R-spondins (RSPOs), such as RSPO2, are secreted proteins that regulate beta-catenin (CTNNB1; MIM 116806) signaling (Kim et al., 2006 [PubMed 16357527]).[supplied by OMIM, Mar 2008]

Chromosome

8

Cytoband

q23.1

Chromosome location (bp)

107899316 - 108083648

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147655 (version 83.38)

Entrez gene

340419

UniProt

Q6UXX9 (UniProt - Evidence at protein level)

neXtProt

NX_Q6UXX9

Antibodypedia

RSPO2 antibodies

PROTEIN BROWSER

RSPO2-001
RSPO2-002
RSPO2-003
RSPO2-004
RSPO2-005
RSPO2-006
RSPO2-007
RSPO2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RSPO2-001
ENSP00000276659
ENST00000276659
Q6UXX9 [Direct mapping]
R-spondin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001649 [osteoblast differentiation]
GO:0001664 [G-protein coupled receptor binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0016055 [Wnt signaling pathway]
GO:0030282 [bone mineralization]
GO:0035115 [embryonic forelimb morphogenesis]
GO:0035116 [embryonic hindlimb morphogenesis]
GO:0042489 [negative regulation of odontogenesis of dentin-containing tooth]
GO:0060437 [lung growth]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0060535 [trachea cartilage morphogenesis]
GO:0071542 [dopaminergic neuron differentiation]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
243 aa
28.3 kDa
Yes 0
RSPO2-002
ENSP00000427937
ENST00000517781
Q6UXX9 [Direct mapping]
R-spondin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0016055 [Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
179 aa
21 kDa
Yes 0
RSPO2-003
ENSP00000428940
ENST00000517939
Q6UXX9 [Direct mapping]
R-spondin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0016055 [Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
176 aa
20.4 kDa
No 0
RSPO2-004
ENSP00000430973
ENST00000522333
E5RGU9 [Direct mapping]
R-spondin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
77 aa
9.1 kDa
Yes 0
RSPO2-005
ENSP00000430010
ENST00000521956
E5RH25 [Direct mapping]
R-spondin-2
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
121 aa
14.2 kDa
Yes 0
RSPO2-006
ENSP00000429159
ENST00000520026
E5RJA2 [Direct mapping]
R-spondin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
89 aa
10.2 kDa
No 0
RSPO2-007
ENSP00000430485
ENST00000521757
E5RJU7 [Direct mapping]
R-spondin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
89 aa
10.2 kDa
No 0
RSPO2-008
ENSP00000428614
ENST00000521502
E5RHC3 [Direct mapping]
R-spondin-2
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0005615 [extracellular space]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
168 aa
19.6 kDa
No 0

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