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CER1

CANCER ATLAS

Gene description

 Cerberus 1, DAN family BMP antagonist

Protein class

 Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019917

GENE INFORMATION

Gene name

 CER1 (HGNC Symbol)

Synonyms

 DAND4

Description

 Cerberus 1, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p22.3

Chromosome location (bp)

 14719724 - 14722717

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147869 (version 83.38)

Entrez gene

 9350

UniProt

 O95813 (UniProt - Evidence at protein level)

neXtProt

 NX_O95813

Antibodypedia

 CER1 antibodies

PROTEIN BROWSER
CER1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CER1-001
ENSP00000370297
ENST00000380911
O95813 [Direct mapping]
Cerberus
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001657 [ureteric bud development]
GO:0003419 [growth plate cartilage chondrocyte proliferation]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007369 [gastrulation]
GO:0007399 [nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009948 [anterior/posterior axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0016015 [morphogen activity]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030282 [bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0035582 [sequestering of BMP in extracellular matrix]
GO:0036122 [BMP binding]
GO:0042074 [cell migration involved in gastrulation]
GO:0042803 [protein homodimerization activity]
GO:0048263 [determination of dorsal identity]
GO:0071773 [cellular response to BMP stimulus]
GO:2000381 [negative regulation of mesoderm development]
Show all
 267 aa
30.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.