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CER1

GENERAL INFORMATION

Gene name

 CER1

Gene description

 Cerberus 1, DAN family BMP antagonist

Protein class

 Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (epididymis)
GTEx:Not detected
FANTOM5:Not detected

Protein evidence

 Evidence at protein level

Protein expression

 RNA-based expert annotation gave inconclusive results.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA019917
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Bronchus

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (epididymis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 CER1 (HGNC Symbol)

Synonyms

 DAND4

Description

 Cerberus 1, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p22.3

Chromosome location (bp)

 14719724 - 14722717

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147869 (version 83.38)

Entrez gene

 9350

UniProt

 O95813 (UniProt - Evidence at protein level)

neXtProt

 NX_O95813

Antibodypedia

 CER1 antibodies

PROTEIN BROWSER
CER1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CER1-001
ENSP00000370297
ENST00000380911
O95813 [Direct mapping]
Cerberus
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0001657 [ureteric bud development]
GO:0003419 [growth plate cartilage chondrocyte proliferation]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007369 [gastrulation]
GO:0007399 [nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0009948 [anterior/posterior axis specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0016015 [morphogen activity]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030282 [bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0032926 [negative regulation of activin receptor signaling pathway]
GO:0035582 [sequestering of BMP in extracellular matrix]
GO:0036122 [BMP binding]
GO:0042074 [cell migration involved in gastrulation]
GO:0042803 [protein homodimerization activity]
GO:0048263 [determination of dorsal identity]
GO:0071773 [cellular response to BMP stimulus]
GO:2000381 [negative regulation of mesoderm development]
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 267 aa
30.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.