Tissue expression of PLPPR1 - Summary - The Human Protein Atlas

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PLPPR1

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PLPPR1
Gene description	Phospholipid phosphatase related 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, kidney)
GTEx:	Tissue enhanced (caudate, hippocampus)
FANTOM5:	Tissue enhanced (caudate, hippocampus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in glial cells.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. External characterization data supports antibody staining. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA014968
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, kidney)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, hippocampus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate, hippocampus)

GENE INFORMATION
Gene name	PLPPR1 (HGNC Symbol)
Synonyms	FLJ20300, LPPR1, MGC26189, PRG-3
Description	Phospholipid phosphatase related 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q31.1
Chromosome location (bp)	101028709 - 101325135
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148123 (version 83.38)
Entrez gene	54886
UniProt	Q8TBJ4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TBJ4
Antibodypedia	PLPPR1 antibodies

PROTEIN BROWSER

PLPPR1-001	PLPPR1-002	PLPPR1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPPR1-001 ENSP00000410223 ENST00000456287	M9MML5 [Direct mapping] Lipid phosphate phosphatase-related protein type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0007399 [nervous system development] GO:0016021 [integral component of membrane] Show all	103 aa 11.6 kDa	No	2
PLPPR1-002 ENSP00000364008 ENST00000374874	Q8TBJ4 [Target identity:100%; Query identity:100%] Lipid phosphate phosphatase-related protein type 1 A0A024R154 [Direct mapping] Lipid phosphate phosphatase-related protein type 1; Plasticity related gene 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0016021 [integral component of membrane] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	325 aa 35.8 kDa	No	6
PLPPR1-003 ENSP00000378496 ENST00000395056	Q8TBJ4 [Target identity:100%; Query identity:100%] Lipid phosphate phosphatase-related protein type 1 A0A024R154 [Direct mapping] Lipid phosphate phosphatase-related protein type 1; Plasticity related gene 3, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0016021 [integral component of membrane] GO:0042577 [lipid phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	325 aa 35.8 kDa	No	6

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.