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SURF4

GENERAL INFORMATION

Gene name

 SURF4

Gene description

 Surfeit 4

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membrane expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA064613
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SURF4 (HGNC Symbol)

Synonyms

 ERV29, FLJ22993, MGC102753

Description

 Surfeit 4 (HGNC Symbol)

Entrez gene summary

 This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 9

Cytoband

 q34.2

Chromosome location (bp)

 133361449 - 133376166

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148248 (version 83.38)

Entrez gene

 6836

UniProt

 O15260 (UniProt - Evidence at protein level)

neXtProt

 NX_O15260

Antibodypedia

 SURF4 antibodies

PROTEIN BROWSER
SURF4-001
SURF4-002
SURF4-004
SURF4-201
SURF4-202
SURF4-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SURF4-001
ENSP00000361057
ENST00000371989
O15260 [Direct mapping]
Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0007030 [Golgi organization]
GO:0010638 [positive regulation of organelle organization]
GO:0016021 [integral component of membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Show all
 269 aa
30.4 kDa 		No 8
SURF4-002
ENSP00000419853
ENST00000485435
O15260 [Direct mapping]
Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0007030 [Golgi organization]
GO:0010638 [positive regulation of organelle organization]
GO:0016021 [integral component of membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Show all
 159 aa
18 kDa 		No 4
SURF4-004
ENSP00000361059
ENST00000371991
Q5T8U5 [Direct mapping]
Surfeit 4; Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 186 aa
21.1 kDa 		No 5
SURF4-201
ENSP00000446061
ENST00000545297
O15260 [Direct mapping]
Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0007030 [Golgi organization]
GO:0010638 [positive regulation of organelle organization]
GO:0016021 [integral component of membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Show all
 128 aa
14.9 kDa 		No 2
SURF4-202
ENSP00000481666
ENST00000613129
B7Z1G8 [Direct mapping]
Surfeit 4, isoform CRA_b; Surfeit locus protein 4; cDNA FLJ50444, highly similar to Surfeit locus protein 4; cDNA FLJ61766, highly similar to Surfeit locus protein 4; cDNA, FLJ79379, highly similar to Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 226 aa
25.5 kDa 		No 7
SURF4-203
ENSP00000483216
ENST00000618229
B7Z1G8 [Direct mapping]
Surfeit 4, isoform CRA_b; Surfeit locus protein 4; cDNA FLJ50444, highly similar to Surfeit locus protein 4; cDNA FLJ61766, highly similar to Surfeit locus protein 4; cDNA, FLJ79379, highly similar to Surfeit locus protein 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 226 aa
25.5 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.