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PTGES2

CANCER ATLAS

Gene description

 Prostaglandin E synthase 2

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA020733

GENE INFORMATION

Gene name

 PTGES2 (HGNC Symbol)

Synonyms

 C9orf15, FLJ14038

Description

 Prostaglandin E synthase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 128120693 - 128128462

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148334 (version 83.38)

Entrez gene

 80142

UniProt

 Q9H7Z7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H7Z7

Antibodypedia

 PTGES2 antibodies

PROTEIN BROWSER
PTGES2-001
PTGES2-007
PTGES2-201
PTGES2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGES2-001
ENSP00000345341
ENST00000338961
Q9H7Z7 [Direct mapping]
Prostaglandin E synthase 2 Prostaglandin E synthase 2 truncated form
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Enzymes
   ENZYME proteins
   Isomerase
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001516 [prostaglandin biosynthetic process]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0009055 [electron carrier activity]
GO:0015035 [protein disulfide oxidoreductase activity]
GO:0016021 [integral component of membrane]
GO:0016829 [lyase activity]
GO:0020037 [heme binding]
GO:0043295 [glutathione binding]
GO:0045454 [cell redox homeostasis]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046903 [secretion]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050220 [prostaglandin-E synthase activity]
GO:0055114 [oxidation-reduction process]
Show all
 377 aa
41.9 kDa 		No 0
PTGES2-007
ENSP00000411378
ENST00000449878
X6RJ95 [Direct mapping]
Prostaglandin E synthase 2
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 265 aa
29.1 kDa 		No 0
PTGES2-201
ENSP00000277462
ENST00000277462
A6NHH0 [Direct mapping]
Prostaglandin E synthase 2; Prostaglandin E synthase 2, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
21.3 kDa 		No 0
PTGES2-202
ENSP00000482913
ENST00000617202
A6NHH0 [Direct mapping]
Prostaglandin E synthase 2; Prostaglandin E synthase 2, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
21.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.