Cell atlas - PTGES2 - The Human Protein Atlas

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PTGES2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	PTGES2
Gene description	Prostaglandin E synthase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA020631
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA020631	A-431	Mitochondria
	HPA020631	U-2 OS	Mitochondria	Intensity
	HPA020631	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	PTGES2 (HGNC Symbol)
Synonyms	C9orf15, FLJ14038
Description	Prostaglandin E synthase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	128120693 - 128128462
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000148334 (version 83.38)
Entrez gene	80142
UniProt	Q9H7Z7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H7Z7
Antibodypedia	PTGES2 antibodies

PROTEIN BROWSER

PTGES2-001	PTGES2-007	PTGES2-201	PTGES2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGES2-001 ENSP00000345341 ENST00000338961	Q9H7Z7 [Direct mapping] Prostaglandin E synthase 2 Prostaglandin E synthase 2 truncated form Show all	Enzymes ENZYME proteins Isomerase SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001516 [prostaglandin biosynthetic process] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0009055 [electron carrier activity] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016021 [integral component of membrane] GO:0016829 [lyase activity] GO:0020037 [heme binding] GO:0043295 [glutathione binding] GO:0045454 [cell redox homeostasis] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046903 [secretion] GO:0048471 [perinuclear region of cytoplasm] GO:0050220 [prostaglandin-E synthase activity] GO:0055114 [oxidation-reduction process] Show all	377 aa 41.9 kDa	No	0
PTGES2-007 ENSP00000411378 ENST00000449878	X6RJ95 [Direct mapping] Prostaglandin E synthase 2 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		265 aa 29.1 kDa	No	0
PTGES2-201 ENSP00000277462 ENST00000277462	A6NHH0 [Direct mapping] Prostaglandin E synthase 2; Prostaglandin E synthase 2, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		186 aa 21.3 kDa	No	0
PTGES2-202 ENSP00000482913 ENST00000617202	A6NHH0 [Direct mapping] Prostaglandin E synthase 2; Prostaglandin E synthase 2, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		186 aa 21.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.