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PTGES

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GENERAL INFORMATION

Gene name

 PTGES

Gene description

 Prostaglandin E synthase

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the endoplasmic reticulum.

RNA cell category

 Cell line enhanced (U-2197, HaCaT, BEWO)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Endoplasmic reticulum (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA045064
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197, HaCaT, BEWO)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the endoplasmic reticulum.

Main location

 Endoplasmic reticulum (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA045064 A549 Endoplasmic reticulum Intensity
HPA045064 SiHa Endoplasmic reticulum Intensity

GENE INFORMATION

Gene name

 PTGES (HGNC Symbol)

Synonyms

 MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12

Description

 Prostaglandin E synthase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 129738331 - 129753047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148344 (version 83.38)

Entrez gene

 9536

UniProt

 O14684 (UniProt - Evidence at protein level)

neXtProt

 NX_O14684

Antibodypedia

 PTGES antibodies

PROTEIN BROWSER
PTGES-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGES-001
ENSP00000342385
ENST00000340607
O14684 [Direct mapping]
Prostaglandin E synthase
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Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001516 [prostaglandin biosynthetic process]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006693 [prostaglandin metabolic process]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032526 [response to retinoic acid]
GO:0034097 [response to cytokine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051592 [response to calcium ion]
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 152 aa
17.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.