Fields »
ABOUT
HELP
BLOG
PTGES

GENERAL INFORMATION

Gene name

 PTGES

Gene description

 Prostaglandin E synthase

Protein class

 Enzymes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle, placenta)
GTEx:Mixed
FANTOM5:Group enriched (seminal vesicle, placenta)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most prominent in seminal vesicle, placenta and urinary bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 1 antibody.
HPA045064
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (seminal vesicle, placenta)

GENE INFORMATION

Gene name

 PTGES (HGNC Symbol)

Synonyms

 MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12

Description

 Prostaglandin E synthase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 129738331 - 129753047

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148344 (version 83.38)

Entrez gene

 9536

UniProt

 O14684 (UniProt - Evidence at protein level)

neXtProt

 NX_O14684

Antibodypedia

 PTGES antibodies

PROTEIN BROWSER
PTGES-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTGES-001
ENSP00000342385
ENST00000340607
O14684 [Direct mapping]
Prostaglandin E synthase
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001516 [prostaglandin biosynthetic process]
GO:0002526 [acute inflammatory response]
GO:0002544 [chronic inflammatory response]
GO:0005641 [nuclear envelope lumen]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006693 [prostaglandin metabolic process]
GO:0007165 [signal transduction]
GO:0008285 [negative regulation of cell proliferation]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0032496 [response to lipopolysaccharide]
GO:0032526 [response to retinoic acid]
GO:0034097 [response to cytokine]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043295 [glutathione binding]
GO:0044281 [small molecule metabolic process]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050220 [prostaglandin-E synthase activity]
GO:0051592 [response to calcium ion]
Show all
 152 aa
17.1 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.