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GLUD1

GENERAL INFORMATION

Gene name

 GLUD1

Gene description

 Glutamate dehydrogenase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA042492 , HPA044839
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GLUD1 (HGNC Symbol)

Synonyms

 GDH, GLUD

Description

 Glutamate dehydrogenase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes glutamate dehydrogenase protein; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.[provided by RefSeq, Sep 2009]

Chromosome

 10

Cytoband

 q23.2

Chromosome location (bp)

 87050486 - 87094866

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148672 (version 83.38)

Entrez gene

 2746

UniProt

 P00367 (UniProt - Evidence at protein level)

neXtProt

 NX_P00367

Antibodypedia

 GLUD1 antibodies

PROTEIN BROWSER
GLUD1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLUD1-001
ENSP00000277865
ENST00000277865
P00367 [Direct mapping]
Glutamate dehydrogenase 1, mitochondrial
E9KL48 [Target identity:100%; Query identity:100%]
Epididymis tissue sperm binding protein Li 18mP; Glutamate dehydrogenase 1, isoform CRA_d
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004352 [glutamate dehydrogenase (NAD+) activity]
GO:0004353 [glutamate dehydrogenase [NAD(P)+] activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006520 [cellular amino acid metabolic process]
GO:0006537 [glutamate biosynthetic process]
GO:0006538 [glutamate catabolic process]
GO:0006541 [glutamine metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0016491 [oxidoreductase activity]
GO:0021762 [substantia nigra development]
GO:0032024 [positive regulation of insulin secretion]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042802 [identical protein binding]
GO:0043531 [ADP binding]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070403 [NAD+ binding]
GO:0070728 [leucine binding]
GO:0072350 [tricarboxylic acid metabolic process]
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 558 aa
61.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.