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MKI67

GENERAL INFORMATION

Gene name

 MKI67

Gene description

 Marker of proliferation Ki-67

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow)
GTEx:Tissue enhanced (esophagus)
FANTOM5:Tissue enhanced (appendix, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression most abundant in germinal center cells and in a subset of cells in several tissues including squamous epithelia, cells in seminiferous ducts and the gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 4 antibodies.
HPA000451 , HPA001164 , CAB000058 , CAB068198
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, tonsil)

GENE INFORMATION

Gene name

 MKI67 (HGNC Symbol)

Synonyms

 MIB-, PPP1R105

Description

 Marker of proliferation Ki-67 (HGNC Symbol)

Entrez gene summary

 This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Chromosome

 10

Cytoband

 q26.2

Chromosome location (bp)

 128096659 - 128126385

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000148773 (version 83.38)

Entrez gene

 4288

UniProt

 P46013 (UniProt - Evidence at protein level)

neXtProt

 NX_P46013

Antibodypedia

 MKI67 antibodies

PROTEIN BROWSER
MKI67-001
MKI67-002
MKI67-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MKI67-001
ENSP00000357643
ENST00000368654
P46013 [Direct mapping]
Antigen KI-67
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000775 [chromosome, centromeric region]
GO:0000793 [condensed chromosome]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006259 [DNA metabolic process]
GO:0007126 [meiotic nuclear division]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0030212 [hyaluronan metabolic process]
GO:0031100 [organ regeneration]
GO:0034605 [cellular response to heat]
GO:0044822 [poly(A) RNA binding]
GO:0072574 [hepatocyte proliferation]
GO:1990705 [cholangiocyte proliferation]
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 3256 aa
358.7 kDa 		No 0
MKI67-002
ENSP00000357642
ENST00000368653
P46013 [Direct mapping]
Antigen KI-67
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
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 2896 aa
319.4 kDa 		No 0
MKI67-201
ENSP00000479215
ENST00000617118
A0A087WV66 [Direct mapping]
Antigen KI-67
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 3255 aa
358.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.