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SYT8

CANCER ATLAS

Gene description

 Synaptotagmin VIII

Protein class

 Predicted membrane proteins

Protein evidence

 Evidence at transcript level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA052700

GENE INFORMATION

Gene name

 SYT8 (HGNC Symbol)

Synonyms

 DKFZp434K0322

Description

 Synaptotagmin VIII (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

 11

Cytoband

 p15.5

Chromosome location (bp)

 1828307 - 1837521

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000149043 (version 83.38)

Entrez gene

 90019

UniProt

 Q8NBV8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8NBV8

Antibodypedia

 SYT8 antibodies

PROTEIN BROWSER
SYT8-002
SYT8-004
SYT8-008
SYT8-010
SYT8-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SYT8-002
ENSP00000371394
ENST00000381968
Q8NBV8 [Direct mapping]
Synaptotagmin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0001669 [acrosomal vesicle]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007340 [acrosome reaction]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0048306 [calcium-dependent protein binding]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 401 aa
44.1 kDa 		No 1
SYT8-004
ENSP00000343691
ENST00000341958
A6NCR4 [Direct mapping]
Synaptotagmin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 387 aa
42.4 kDa 		No 1
SYT8-008
ENSP00000371406
ENST00000381978
H0Y3G9 [Direct mapping]
Synaptotagmin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 400 aa
43.8 kDa 		No 1
SYT8-010
ENSP00000387678
ENST00000417052
C9K032 [Direct mapping]
Synaptotagmin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 99 aa
10 kDa 		No 1
SYT8-011
ENSP00000392469
ENST00000430303
C9J253 [Direct mapping]
Synaptotagmin-8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0019905 [syntaxin binding]
GO:0030276 [clathrin binding]
GO:0030672 [synaptic vesicle membrane]
GO:0048488 [synaptic vesicle endocytosis]
GO:0048791 [calcium ion-dependent exocytosis of neurotransmitter]
Show all
 102 aa
10.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.