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SSRP1

GENERAL INFORMATION

Gene name

 SSRP1

Gene description

 Structure specific recognition protein 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA002697
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Breast
N/A
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SSRP1 (HGNC Symbol)

Synonyms

 FACT80

Description

 Structure specific recognition protein 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 57325985 - 57335877

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000149136 (version 83.38)

Entrez gene

 6749

UniProt

 Q08945 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08945

Antibodypedia

 SSRP1 antibodies

PROTEIN BROWSER
SSRP1-001
SSRP1-003
SSRP1-004
SSRP1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSRP1-001
ENSP00000278412
ENST00000278412
Q08945 [Direct mapping]
FACT complex subunit SSRP1
A0A024R4Z6 [Target identity:100%; Query identity:100%]
Structure specific recognition protein 1, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0044822 [poly(A) RNA binding]
GO:0050434 [positive regulation of viral transcription]
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 709 aa
81.1 kDa 		No 0
SSRP1-003
ENSP00000434546
ENST00000529002
E9PPZ7 [Direct mapping]
FACT complex subunit SSRP1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
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 89 aa
9.9 kDa 		No 0
SSRP1-004
ENSP00000431154
ENST00000526696
E9PMD4 [Direct mapping]
FACT complex subunit SSRP1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006355 [regulation of transcription, DNA-templated]
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 173 aa
19.8 kDa 		No 0
SSRP1-005
ENSP00000489564
ENST00000635721
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 225 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.