Expression of INCENP in cancer - Summary

CANCER ATLAS

Gene description

Inner centromere protein antigens 135/155kDa

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Lymphoma

STAINING SUMMARY

CAB013292

GENE INFORMATION
Gene name	INCENP (HGNC Symbol)
Synonyms	FLJ31633
Description	Inner centromere protein antigens 135/155kDa (HGNC Symbol)
Entrez gene summary	In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62123973 - 62153163
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149503 (version 83.38)
Entrez gene	3619
UniProt	Q9NQS7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQS7
Antibodypedia	INCENP antibodies

PROTEIN BROWSER

INCENP-001	INCENP-002	INCENP-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INCENP-001 ENSP00000378295 ENST00000394818	Q9NQS7 [Direct mapping] Inner centromere protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000795 [synaptonemal complex] GO:0000800 [lateral element] GO:0000801 [central element] GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005721 [pericentric heterochromatin] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0010369 [chromocenter] GO:0030496 [midbody] GO:0043234 [protein complex] Show all	918 aa 105.4 kDa	No	0
INCENP-002 ENSP00000278849 ENST00000278849	Q9NQS7 [Direct mapping] Inner centromere protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000910 [cytokinesis] GO:0005515 [protein binding] GO:0005721 [pericentric heterochromatin] GO:0005819 [spindle] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0043234 [protein complex] Show all	914 aa 105 kDa	No	0
INCENP-004 ENSP00000433100 ENST00000533896	E9PM67 [Direct mapping] Inner centromere protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		167 aa 19 kDa	No	0