Expression of ADGRL3 in cancer - Summary

CANCER ATLAS

Gene description

Adhesion G protein-coupled receptor L3

Protein class

G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Ovarian cancer

STAINING SUMMARY

HPA015027	HPA015762	CAB022698

GENE INFORMATION
Gene name	ADGRL3 (HGNC Symbol)
Synonyms	KIAA0768, LEC3, LPHN3
Description	Adhesion G protein-coupled receptor L3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q13.1
Chromosome location (bp)	61201258 - 62078335
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000150471 (version 83.38)
Entrez gene	23284
UniProt	Q9HAR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HAR2
Antibodypedia	ADGRL3 antibodies

PROTEIN BROWSER

ADGRL3-001	ADGRL3-002	ADGRL3-003	ADGRL3-004	ADGRL3-006	ADGRL3-007	ADGRL3-008	ADGRL3-009	ADGRL3-010	ADGRL3-011	ADGRL3-012	ADGRL3-013	ADGRL3-014	ADGRL3-015	ADGRL3-016	ADGRL3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRL3-001 ENSP00000423388 ENST00000512091	Q9HAR2 [Direct mapping] Latrophilin-3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007416 [synapse assembly] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0098609 [cell-cell adhesion] Show all	1240 aa 139.3 kDa	Yes	7
ADGRL3-002 ENSP00000424402 ENST00000502815	H0Y9K5 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	918 aa 102.3 kDa	No	7
ADGRL3-003 ENSP00000422533 ENST00000514591	Q9HAR2 [Direct mapping] Latrophilin-3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001764 [neuron migration] GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007416 [synapse assembly] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0031987 [locomotion involved in locomotory behavior] GO:0042220 [response to cocaine] GO:0051965 [positive regulation of synapse assembly] GO:0098609 [cell-cell adhesion] Show all	1469 aa 164.6 kDa	Yes	7
ADGRL3-004 ENSP00000421476 ENST00000507164	E7EX52 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1342 aa 149.6 kDa	Yes	7
ADGRL3-006 ENSP00000425201 ENST00000514157	E7ES20 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1274 aa 142.7 kDa	Yes	7
ADGRL3-007 ENSP00000421627 ENST00000508946	E7EW95 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1512 aa 169.1 kDa	Yes	7
ADGRL3-008 ENSP00000420931 ENST00000506720	E7EUW2 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1580 aa 176.1 kDa	Yes	7
ADGRL3-009 ENSP00000425884 ENST00000506746	E7ETE3 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1571 aa 174.9 kDa	Yes	7
ADGRL3-010 ENSP00000424258 ENST00000514996	E9PBG4 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1503 aa 168 kDa	Yes	7
ADGRL3-011 ENSP00000424030 ENST00000508693	E7EN28 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1351 aa 150.8 kDa	Yes	7
ADGRL3-012 ENSP00000423434 ENST00000504896	E7ENK1 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1283 aa 143.8 kDa	Yes	7
ADGRL3-013 ENSP00000423787 ENST00000509896	E7EUP0 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1308 aa 146.2 kDa	Yes	7
ADGRL3-014 ENSP00000425033 ENST00000511324	E7ESV6 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1299 aa 145.1 kDa	Yes	7
ADGRL3-015 ENSP00000424120 ENST00000506700	E7EMR3 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1231 aa 138.1 kDa	Yes	7
ADGRL3-016 ENSP00000421372 ENST00000507625	E7EVD6 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	1528 aa 170.4 kDa	Yes	7
ADGRL3-201 ENSP00000439831 ENST00000545650	A0A0A0MTH7 [Direct mapping] Protein ADGRL3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1345 aa 150.4 kDa	No	7