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MTMR12

GENERAL INFORMATION

Gene name

 MTMR12

Gene description

 Myotubularin related protein 12

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA051333
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MTMR12 (HGNC Symbol)

Synonyms

 3-PAP, 3PAP, FLJ20476, KIAA1682, PIP3AP

Description

 Myotubularin related protein 12 (HGNC Symbol)

Entrez gene summary

 Phosphatidylinositide 3-kinase-derived membrane-anchored phosphatidylinositides, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), regulate diverse cellular processes. The protein encoded by this gene functions as an adaptor subunit in a complex with an active PtdIns(3)P 3-phosphatase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Chromosome

 5

Cytoband

 p13.3

Chromosome location (bp)

 32226994 - 32313009

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000150712 (version 83.38)

Entrez gene

 54545

UniProt

 Q9C0I1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C0I1

Antibodypedia

 MTMR12 antibodies

PROTEIN BROWSER
MTMR12-001
MTMR12-002
MTMR12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MTMR12-001
ENSP00000371577
ENST00000382142
Q9C0I1 [Direct mapping]
Myotubularin-related protein 12
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0019208 [phosphatase regulator activity]
GO:0050790 [regulation of catalytic activity]
GO:1901998 [toxin transport]
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 747 aa
86.1 kDa 		No 0
MTMR12-002
ENSP00000264934
ENST00000264934
Q9C0I1 [Direct mapping]
Myotubularin-related protein 12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0019208 [phosphatase regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 637 aa
73.2 kDa 		No 0
MTMR12-003
ENSP00000280285
ENST00000280285
Q9C0I1 [Direct mapping]
Myotubularin-related protein 12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0019208 [phosphatase regulator activity]
GO:0050790 [regulation of catalytic activity]
Show all
 693 aa
79.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.