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Rare cases of testis, urothelial and head and neck cancers showed moderate nuclear positivity. Most remaining cancer tissues were weakly stained or negative.
Most cancer tissues showed weak to moderate cytoplasmic and nuclear positivity.
GENE INFORMATION
Gene name
FOXO1 (HGNC Symbol)
Synonyms
FKH1, FKHR, FOXO1A
Description
Forkhead box O1 (HGNC Symbol)
Entrez gene summary
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0000989 [transcription factor activity, transcription factor binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001223 [transcription coactivator binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001568 [blood vessel development] GO:0001659 [temperature homeostasis] GO:0001678 [cellular glucose homeostasis] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006473 [protein acetylation] GO:0006914 [autophagy] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009267 [cellular response to starvation] GO:0009653 [anatomical structure morphogenesis] GO:0010508 [positive regulation of autophagy] GO:0030154 [cell differentiation] GO:0031018 [endocrine pancreas development] GO:0031625 [ubiquitin protein ligase binding] GO:0032868 [response to insulin] GO:0032869 [cellular response to insulin stimulus] GO:0032873 [negative regulation of stress-activated MAPK cascade] GO:0034599 [cellular response to oxidative stress] GO:0035947 [regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042593 [glucose homeostasis] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045444 [fat cell differentiation] GO:0045599 [negative regulation of fat cell differentiation] GO:0045722 [positive regulation of gluconeogenesis] GO:0045732 [positive regulation of protein catabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051721 [protein phosphatase 2A binding] GO:0070166 [enamel mineralization] GO:0070301 [cellular response to hydrogen peroxide] GO:0070417 [cellular response to cold] GO:0071455 [cellular response to hyperoxia] GO:0071549 [cellular response to dexamethasone stimulus] GO:0071732 [cellular response to nitric oxide] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:0097150 [neuronal stem cell population maintenance] GO:1902617 [response to fluoride] GO:2000177 [regulation of neural precursor cell proliferation] GO:2000377 [regulation of reactive oxygen species metabolic process] GO:2000505 [regulation of energy homeostasis]