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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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FOXO1
  • TISSUE

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TISSUE ATLAS PRIMARY DATA
MOUSE BRAIN

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

FOXO1

Gene description

Forkhead box O1

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression at variable levels in several different cell types.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
HPA001252 , CAB022326
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

FOXO1 (HGNC Symbol)

Synonyms

FKH1, FKHR, FOXO1A

Description

Forkhead box O1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

Chromosome

13

Cytoband

q14.11

Chromosome location (bp)

40555667 - 40666597

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000150907 (version 83.38)

Entrez gene

2308

UniProt

Q12778 (UniProt - Evidence at protein level)

neXtProt

NX_Q12778

Antibodypedia

FOXO1 antibodies

PROTEIN BROWSER

FOXO1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FOXO1-001
ENSP00000368880
ENST00000379561
Q12778 [Direct mapping]
Forkhead box protein O1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0000989 [transcription factor activity, transcription factor binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001223 [transcription coactivator binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001568 [blood vessel development]
GO:0001659 [temperature homeostasis]
GO:0001678 [cellular glucose homeostasis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006473 [protein acetylation]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008134 [transcription factor binding]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009267 [cellular response to starvation]
GO:0009653 [anatomical structure morphogenesis]
GO:0010508 [positive regulation of autophagy]
GO:0030154 [cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032868 [response to insulin]
GO:0032869 [cellular response to insulin stimulus]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034599 [cellular response to oxidative stress]
GO:0035947 [regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042593 [glucose homeostasis]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045444 [fat cell differentiation]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045722 [positive regulation of gluconeogenesis]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051721 [protein phosphatase 2A binding]
GO:0070166 [enamel mineralization]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070417 [cellular response to cold]
GO:0071455 [cellular response to hyperoxia]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097150 [neuronal stem cell population maintenance]
GO:1902617 [response to fluoride]
GO:2000177 [regulation of neural precursor cell proliferation]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000505 [regulation of energy homeostasis]
Show all
655 aa
69.7 kDa
No 0

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